Use of Anticoagulants to prevent Adhesion Syndrome in NMRI Strain Mice: An Experimental Study

Abstract

Abdominal adhesions involve the activation of the coagulation process and a series of enzymatic substrate activation reactions that generate the formation of fibrin from the activation of fibrinogen, leading to complications such as intestinal obstructions. Objective: To determine whether the use of anticoagulants such as Enoxaparin and Rivaroxaban contributes to the prevention of adhesional syndrome in NMRI strain mice undergoing surgery. Methodology: A preclinical, concurrent experimental study with a controlled, randomized, double-blind design was conducted in an animal model, with statistical analysis to determine the efficacy of pharmacological interventions. The sample consisted of 40 NMRI strain mice, divided into 4 surgically treated groups; three groups received a protocol with anticoagulants, and one control group did not. One month later, the mice underwent a second surgery to evaluate the impact on the development of adhesions. Results: are expressed using descriptive, percentage, and inferential statistics. A statistically significant difference (p < 0,005) was found when comparing the case groups (adhesions in 22, 20, and 20%, respectively) with the control group, which showed 100% postoperative adhesions. Conclusions: Rivaroxaban and Enoxaparin inhibit the post-injury peritoneal adhesion process in NMRI strain mice, highlighting the effectiveness of both anticoagulants.